Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541492 | 0.87 | SRD5A1 (0.47) | ALDH1A1HSD17B10SMN1; SMN2SRD5A1CYP2D6 | |
| SCHEMBL20353827 | 0.85 | HSD17B10 (0.43) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2CYP2D6 | |
| SCHEMBL15625443 | 0.82 | BRD4 (0.42) | ALDH1A1BRD4HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL24359222 | 0.82 | SRD5A1 (0.41) | BRD4SMN1; SMN2SRD5A1CYP2D6CYP2C9 | |
| SCHEMBL30926398 | 0.82 | CYP2D6 (0.46) | BRD4L3MBTL1SMN1; SMN2SRD5A1CYP2D6 | |
| SCHEMBL20942631 | 0.80 | SRD5A1 (0.40) | ALDH1A1BRD4L3MBTL1SMN1; SMN2SRD5A1 | |
| SCHEMBL5956393 | 0.77 | SMN1; SMN2 (0.55) | BRD4HSD17B10L3MBTL1SMN1; SMN2SRD5A1 | |
| SCHEMBL29896794 | 0.77 | SMN1; SMN2 (0.55) | BRD4HSD17B10L3MBTL1SMN1; SMN2SRD5A1 | |
| SCHEMBL5023390 | 0.77 | SRD5A1 (0.54) | ALDH1A1BRD4HSD17B10L3MBTL1SRD5A1 | |
| SCHEMBL24123320 | 0.76 | ALDH1A1 (0.45) | ALDH1A1HSD17B10L3MBTL1SRD5A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358936-B2 | Lysyl oxidase-like 2 inhibitors and uses thereof | PHARMAKEA, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-11072585-B2 | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof | PHARMAKEA, INC. (US) | 2021-07-27 | — | — | US | disclosed |
| US-20210171465-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358936-B2 | Lysyl oxidase-like 2 inhibitors and uses thereof | LOXL2, LOXL1, LOX | ALDH1A1 982/4885BRD4 2041/4885HSD17B10 584/4885 |
| US-20210171465-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | ALDH1A1 982/4885BRD4 2041/4885HSD17B10 584/4885 |
| US-11072585-B2 | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof | LOXL2, LOXL1, LOX | ALDH1A1 1095/4885BRD4 2093/4885HSD17B10 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.