SCHEMBL2348903

SCHEMBL2348903

Cc1c(Cl)nc(C(=O)O)c(Cl)c1N

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.69
HCAR2 Q8TDS4 1/20 0.40
MAPT P10636 3/20 0.39
LMNA P02545 3/20 0.39
GAA P10253 3/20 0.39
ATM Q13315 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
ALDH1A1 P00352 5/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 3/20 0.34
CYP1A2 P05177 2/20 0.34
SLC9A1 P19634 2/20 0.34
FTO Q9C0B1 2/20 0.34
CYP3A4 P08684 1/20 0.34
ALKBH5 Q6P6C2 1/20 0.34
KMO O15229 2/20 0.33
RAD52 P43351 1/20 0.33
NOX1 Q9Y5S8 1/20 0.33
HPGD P15428 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19626005 0.86 TDP1 (0.55) TDP1HCAR2MAPTLMNAGAA
Picloram SCHEMBL13299 0.82 TDP1 (1.00) TDP1HCAR2MAPTLMNAGAA
Picloram SCHEMBL8467014 0.82 TDP1 (1.00) TDP1HCAR2MAPTLMNAGAA
SCHEMBL15032602 0.82 TDP1 (0.53) TDP1HCAR2MAPTALDH1A1MAPK1
Picloram SCHEMBL29388079 0.82 TDP1 (1.00) TDP1HCAR2MAPTLMNAGAA
SCHEMBL29556649 0.81 NPSR1 (0.47) TDP1MAPTLMNAGAAATM
SCHEMBL16029462 0.81 NPSR1 (0.47) TDP1MAPTLMNAGAAATM
Picloram SCHEMBL4936972 0.81 TDP1 (0.89) TDP1HCAR2MAPTLMNAGAA
SCHEMBL2343976 0.81 TDP1 (0.44) TDP1MAPTLMNAGAAATM
Picloram SCHEMBL15437675 0.80 TDP1 (0.96) TDP1HCAR2MAPTLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498413-B1 4-Aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2011-08-31 EP disclosed
EP-1246802-B1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-03-14 EP disclosed
EP-1498413-A1 4-Aminopicolinates and their use as herbicides Dow AgroSciences LLC (US) 2005-01-19 EP disclosed
EP-1246802-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2002-10-09 EP disclosed
US-20010047099-A1 4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC 2001-11-29 US disclosed
US-6297197-B1 DEMONSTRATING A BROAD SPECTRUM OF WEED CONTROL. DOW AGROSCIENCES LLC 2001-10-02 US disclosed
WO-2001051468-A1 4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2001-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010047099-A1 4-aminopicolinates and their use as herbicides AADAT, ABAT, DDT TDP1 3400/4885HCAR2 154/4885MAPT 437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.