Sugi Predict

Sugi Predict / Compounds / SCHEMBL19626005

SCHEMBL19626005

SCHEMBL19626005

Cc1c(Cl)nc(C(=O)O)c(C)c1N

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.55
▸ HCAR2 Q8TDS4 1/20 0.37
▸ ALDH1A1 P00352 7/20 0.37
▸ MAPK1 P28482 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ TSHR P16473 4/20 0.35
▸ CYP1A2 P05177 3/20 0.35
▸ SLC9A1 P19634 2/20 0.35
▸ FTO Q9C0B1 2/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ ALKBH5 Q6P6C2 1/20 0.35
▸ MAPT P10636 3/20 0.34
▸ KMO O15229 2/20 0.34
▸ RAD52 P43351 1/20 0.34
▸ HPGD P15428 4/20 0.33
▸ KDM4E B2RXH2 4/20 0.33
▸ LMNA P02545 3/20 0.33
▸ GAA P10253 3/20 0.33
▸ GLA P06280 3/20 0.33
▸ HSD17B10 Q99714 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2348903 0.86 TDP1 (0.69) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2
SCHEMBL12257176 0.81 TDP1 (0.41) TDP1HCAR2ALDH1A1TSHRMAPT
SCHEMBL19626000 0.79 NPSR1 (0.47) TDP1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL38659069 0.76 ALDH1A1 (0.48) TDP1ALDH1A1MAPK1SMN1; SMN2TSHR
SCHEMBL25280483 0.76 TDP1 (0.50) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2
SCHEMBL15032602 0.75 TDP1 (0.53) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2
SCHEMBL1919221 0.75 HCAR2 (0.39) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2
SCHEMBL7518054 0.75 HCAR2 (0.39) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2
SCHEMBL28831085 0.75 PDE10A (0.41) TDP1ALDH1A1MAPTLMNAGAA
SCHEMBL27884099 0.74 TDP1 (0.45) TDP1HCAR2ALDH1A1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357155-A1 IMPROVED SYNTHESIS OF 4-AMINO-6-(HETEROCYCLIC)PICOLINATES CORTEVA AGRISCIENCE LLC (US) 2023-11-09 — — US disclosed
US-20230174490-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES CORTEVA AGRISCIENCE LLC (US) 2023-06-08 — — US disclosed
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DOW AGROSCIENCES LLC (US) 2017-11-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357155-A1 IMPROVED SYNTHESIS OF 4-AMINO-6-(HETEROCYCLIC)PICOLINATES APC, PPOX, ALAD TDP1 1950/4885HCAR2 2382/4885ALDH1A1 3664/4885
US-20230174490-A1 IMPROVED SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AAAS, AADAC, NPEPPS TDP1 3412/4885HCAR2 1309/4885ALDH1A1 1240/4885
US-20170334878-A1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING DDC, AAAS, AASDHPPT TDP1 1275/4885HCAR2 2874/4885ALDH1A1 1269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.