Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29536743 | 0.87 | MEN1 (0.56) | SMN1; SMN2ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL3187182 | 0.87 | MEN1 (0.56) | SMN1; SMN2ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL29536538 | 0.80 | POLB (0.47) | GAASMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL23501077 | 0.80 | POLB (0.47) | GAASMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL29536398 | 0.78 | AKT1 (0.44) | ALDH1A1POLBCDK2MAPTKDR | |
| SCHEMBL22231493 | 0.73 | ABL1 (0.53) | HPGDHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL10197138 | 0.73 | GAA (0.60) | GAASMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL19263436 | 0.70 | KMT2A (0.56) | SMN1; SMN2ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL3937754 | 0.70 | MAPT (0.49) | MAPT | |
| SCHEMBL1753925 | 0.70 | GAA (0.70) | GAASMN1; SMN2ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939948-B | Novel quinazoline-containing compound, intermediate and application thereof | 苏州美诺医药科技有限公司 | 2022-05-17 | — | — | CN | disclosed |
| WO-2021115432-A1 | NOVEL QUINAZOLINE-CONTAINING COMPOUND, AND INTERMEDIATE THEREOF AND USE THEREOF | 苏州长禾药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| WO-2021115432-A1 | NOVEL QUINAZOLINE-CONTAINING COMPOUND, AND INTERMEDIATE THEREOF AND USE THEREOF | 苏州长禾药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| CN-112939948-A | Novel quinazoline-containing compound, intermediate and application thereof | 苏州长禾药业股份有限公司 | 2021-06-11 | — | — | CN | disclosed |