Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29536538 | 1.00 | POLB (0.47) | POLBNPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29536398 | 0.90 | AKT1 (0.44) | POLBMAPTALDH1A1RAB9AKDR | |
| SCHEMBL3178922 | 0.90 | AKT1 (0.44) | POLBMAPTALDH1A1RAB9AKDR | |
| SCHEMBL23500689 | 0.80 | GAA (0.54) | POLBMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3187182 | 0.78 | MEN1 (0.56) | POLBNPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29536743 | 0.78 | MEN1 (0.56) | POLBNPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2010247 | 0.71 | SMN1; SMN2 (0.69) | POLBNPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5164404 | 0.70 | RAB9A (0.49) | POLBNPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3177749 | 0.70 | AURKA (0.45) | ALDH1A1LMNA | |
| SCHEMBL12522979 | 0.70 | CHRNA7 (0.45) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939948-B | Novel quinazoline-containing compound, intermediate and application thereof | 苏州美诺医药科技有限公司 | 2022-05-17 | — | — | CN | disclosed |
| WO-2021115432-A1 | NOVEL QUINAZOLINE-CONTAINING COMPOUND, AND INTERMEDIATE THEREOF AND USE THEREOF | 苏州长禾药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| WO-2021115432-A1 | NOVEL QUINAZOLINE-CONTAINING COMPOUND, AND INTERMEDIATE THEREOF AND USE THEREOF | 苏州长禾药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| CN-112939948-A | Novel quinazoline-containing compound, intermediate and application thereof | 苏州长禾药业股份有限公司 | 2021-06-11 | — | — | CN | disclosed |