Sugi Predict

Sugi Predict / Compounds / SCHEMBL2350643

SCHEMBL2350643

SCHEMBL2350643

Nc1ccn(-c2ccc(Cl)cc2Cl)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.43
▸ TSHR P16473 2/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ LMNA P02545 3/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ HTT P42858 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ KCNH2 Q12809 2/20 0.38
▸ TP53 P04637 2/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ RPA1 P27694 1/20 0.36
▸ IDO1 P14902 1/20 0.36
▸ CRHR1 P34998 1/20 0.35
▸ OPRM1 P35372 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11464949 0.86 NOTUM (0.43) NOTUMTSHRCYP3A4MAPTSMN1; SMN2
SCHEMBL29572717 0.86 NOTUM (0.43) NOTUMTSHRCYP3A4MAPTSMN1; SMN2
SCHEMBL27859366 0.83 L3MBTL1 (0.39) MEN1GAAKMT2AHTTALDH1A1
SCHEMBL15639297 0.83 BCHE (0.40) CYP3A4LMNAMEN1NPC1POLB
SCHEMBL1799291 0.83 KCNH2 (0.38) LMNAMEN1POLBKMT2AHTT
SCHEMBL29572778 0.83 BCHE (0.40) CYP3A4LMNAMEN1NPC1POLB
SCHEMBL11338020 0.81 NOTUM (0.47) NOTUMTSHRCYP3A4POLBGAA
SCHEMBL30264165 0.79 NOTUM (0.46) NOTUMTSHRCYP3A4LMNAGAA
SCHEMBL16201988 0.79 MAPT (0.53) NOTUMTSHRLMNANPC1GAA
SCHEMBL7476273 0.79 NOTUM (0.46) NOTUMTSHRCYP3A4LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548854-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2023-01-10 — — US disclosed
US-11332448-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2022-05-17 — — US disclosed
CN-113243374-B Heterocyclic compounds as pesticides 拜耳农作物科学股份公司 2022-04-26 — — CN disclosed
CN-113243374-A Heterocyclic compounds as pesticides 拜耳农作物科学股份公司 2021-08-13 — — CN disclosed
CN-108477173-B Heterocyclic compounds as pesticides 拜耳农作物科学股份公司 2021-07-02 — — CN disclosed
US-10961201-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2021-03-30 — — US disclosed
US-20210053924-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2021-02-25 — — US disclosed
US-20210017136-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2021-01-21 — — US disclosed
US-10689348-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2020-06-23 — — US disclosed
US-10435374-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2019-10-08 — — US disclosed
US-9802899-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2017-10-31 — — US disclosed
US-20170305864-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2017-10-26 — — US disclosed
EP-2903440-B1 HETEROCYCLIC COMPOUNDS AS PEST CONTROLLING AGENTS BAYER CROPSCIENCE AG (DE) 2017-09-06 — — EP disclosed
CN-105101800-A Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG 2015-11-25 — — CN disclosed
US-20150239847-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2015-08-27 — — US disclosed
EP-2903440-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES Bayer CropScience AG (DE) 2015-08-12 — — EP disclosed
WO-2014053450-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2014-04-10 — — WO disclosed
US-8486967-B2 Heteroaryl substituted piperidines HOFFMANN-LA ROCHE INC. (US) 2013-07-16 — — US disclosed
US-20110201605-A1 HETEROARYL SUBSTITUTED PIPERIDINES HOFFMANN-LA ROCHE, INC. 2011-08-18 — — US disclosed
EP-0011295-A1 Yellow monoazo dyes of the 2-hydroxydibenzofuran series; their preparation and use for dyeing and printing synthetic hydrophobic fibres Montedison S.p.A. (IT) 1980-05-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10435374-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-20170305864-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-10961201-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-10689348-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-11548854-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-20210053924-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-20110201605-A1 HETEROARYL SUBSTITUTED PIPERIDINES APP, HPGDS, PSEN1 NOTUM 2232/4885TSHR 4608/4885CYP3A4 3281/4885
US-11332448-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-20210017136-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885
US-20150239847-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, ACHE, PTMS NOTUM 274/4885TSHR 2486/4885CYP3A4 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.