Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSL1 | P33121 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16399885 | 0.80 | HSPD1 (0.56) | MAPTRAB9ASMN1; SMN2TP53HSPD1 | |
| SCHEMBL4885296 | 0.80 | HDAC6 (0.61) | MAPTRAB9ASMN1; SMN2TP53HSPD1 | |
| SCHEMBL28605620 | 0.80 | KDM4E (0.74) | MAPTRAB9ASMN1; SMN2TP53HSPD1 | |
| SCHEMBL31247990 | 0.80 | KDM4E (0.74) | MAPTRAB9ASMN1; SMN2TP53HSPD1 | |
| SCHEMBL27256179 | 0.79 | ACSL1 (0.84) | ACSL1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL24634557 | 0.78 | ACSL1 (1.00) | ACSL1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL23542082 | 0.78 | ACSL1 (0.53) | ACSL1MAPTRAB9ATP53ALDH1A1 | |
| SCHEMBL20469750 | 0.78 | ACSL1 (0.53) | ACSL1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6821226 | 0.78 | MAPT (0.72) | MAPTRAB9ASMN1; SMN2TP53HSPD1 | |
| SCHEMBL23542084 | 0.78 | MAPT (0.78) | MAPTRAB9ASMN1; SMN2TP53HSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2021-06-22 | — | — | US | disclosed |
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | JANSSEN VACCINES & PREVENTION B.V. (NL) | 2021-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040963-B2 | Piperazine derivatives for influenza virus inhibitions | HAVCR2, BAZ2A, MAVS | ACSL1 4297/4885MAPT 4595/4885RAB9A 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.