Maleic Acid

Maleic Acid

SCHEMBL235141

C=CC(=O)OCC(CO)(COC(=O)C=C)COC(=O)C=C.O=C(O)/C=C\C(=O)O

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.81
TP53 P04637 4/20 0.81
HIF1A Q16665 3/20 0.81
CYP3A4 P08684 2/20 0.81
MAPK1 P28482 1/20 0.81
SMN1; SMN2 Q16637 1/20 0.81
TSHR P16473 9/20 0.44
THRB P10828 2/20 0.41
HSD17B10 Q99714 1/20 0.39
HCAR2 Q8TDS4 7/20 0.38
HPGD P15428 1/20 0.36
EGLN1 Q9GZT9 1/20 0.33
EGLN3 Q9H6Z9 1/20 0.33
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL230694 0.93 ALDH1A1 (0.71) ALDH1A1TP53HIF1ACYP3A4MAPK1
Acrylic Acid SCHEMBL5851594 0.92 ALDH1A1 (0.88) ALDH1A1TP53HIF1ACYP3A4MAPK1
SCHEMBL151566 0.90 ALDH1A1 (1.00) ALDH1A1TP53HIF1ACYP3A4MAPK1
Acrylic Acid SCHEMBL10861928 0.89 ALDH1A1 (0.81) ALDH1A1TP53HIF1ACYP3A4MAPK1
SCHEMBL6664674 0.88 ALDH1A1 (0.96) ALDH1A1TP53HIF1ACYP3A4MAPK1
Ethylene SCHEMBL21434347 0.88 ALDH1A1 (0.96) ALDH1A1TP53HIF1ACYP3A4MAPK1
SCHEMBL1269051 0.88 ALDH1A1 (0.96) ALDH1A1TP53HIF1ACYP3A4MAPK1
Ammonia Solution, Strong SCHEMBL8679286 0.88 ALDH1A1 (0.96) ALDH1A1TP53HIF1ACYP3A4MAPK1
SCHEMBL235142 0.87 ALDH1A1 (0.60) ALDH1A1TP53HIF1ACYP3A4MAPK1
Ethylene Glycol SCHEMBL5276892 0.86 ALDH1A1 (0.92) ALDH1A1TP53HIF1ACYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218244-A1 CURED FILM AND DISPLAY DEVICE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-07-04 US disclosed
US-20240166791-A1 CURED FILM AND DISPLAY DEVICE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-05-23 US disclosed
WO-2024084904-A1 CURABLE COMPOSITION, CURED FILM, AND DISPLAY DEVICE 住友化学株式会社 2024-04-25 WO disclosed
EP-4332122-A1 CURED FILM AND DISPLAY DEVICE Sumitomo Chemical Company, Limited (JP) 2024-03-06 EP disclosed
EP-4332123-A1 CURED FILM AND DISPLAY DEVICE Sumitomo Chemical Company Limited (JP) 2024-03-06 EP disclosed
WO-2023157561-A1 CURABLE COMPOSITION, CURABLE FILM, AND DISPLAY DEVICE 住友化学株式会社 2023-08-24 WO disclosed
CN-108387954-B Laminate, flexible device, and method for producing laminate 东京应化工业株式会社 2022-01-18 CN disclosed
EP-2553025-B1 COLORED COMPOSITION, INKJET INK, COLOR FILTER AND METHOD OF PRODUCING THE SAME, SOLID-STATE IMAGE SENSOR AND DISPLAY DEVICE FUJIFILM CORP (JP) 2022-01-12 EP disclosed
EP-2246385-B1 RESIN, PIGMENT DISPERSION LIQUID, COLORING CURABLE COMPOSITION, COLOR FILTER PRODUCED BY USING THE COMPOSITION, AND METHOD FOR PRODUCING THE COLOR FILTER FUJIFILM CORP (JP) 2017-11-29 EP disclosed
CN-104035283-B Colored composition, ink for inkjet, color filter and its manufacture method and solid-state image sensors and display device 富士胶片株式会社 2017-11-21 CN disclosed
EP-1702752-A1 EMBOSSED RELEASE PAPER FOR PRODUCTION OF SYNTHETIC LEATHER, SUPPORT THEREOF, SYNTHETIC LEATHER UTILIZING THE RELEASE PAPER AND PROCESS FOR PRODUCING THE SAME Dainippon Printing Co., Ltd. (JP) 2006-09-20 EP disclosed
US-20030118838-A1 Laminate, adhering method and active energy ray-curable composition MITSUBISHI CHEMICAL CORPORATION (JP) 2003-06-26 US disclosed
EP-1275496-A1 LAYERED PRODUCT, BONDING METHOD, AND COMPOSITION CURABLE WITH ACTINIC ENERGY RAY MITSUBISHI CHEMICAL CORPORATION (JP) 2003-01-15 EP disclosed
US-20020014703-A1 Semiconductor flip-chip package and method for the fabrication thereof CAPOTE MIGUEL A (US) 2002-02-07 US disclosed
EP-1001852-A4 POLYMERIZABLE FLUXING AGENTS AND FLUXING ADHESIVE COMPOSITIONS THEREFROM AGUILA TECHNOLOGIES INC (US) 2002-02-06 EP disclosed
US-6297560-B1 Semiconductor flip-chip assembly with pre-applied encapsulating layers Capote, Miguel Albert 2001-10-02 US disclosed
EP-1001852-A1 POLYMERIZABLE FLUXING AGENTS AND FLUXING ADHESIVE COMPOSITIONS THEREFROM Aguila Technologies, Inc. (US) 2000-05-24 EP disclosed
US-6017634-A ELECTRICAL COMPONENT BEING ATTACHED TO CARRIER SUBSTRATE THROUGH TERMINAL CONNECTORS JOINED USING INVENTIVE FLUX; LOW MOISTURE ABSORPTION, CORROSION RESISTANCE, NONHYDROLYZING MIGUEL ALBERT CAPOTE (US) 2000-01-25 US disclosed
US-5985456-A HEAT CURABLE; NONHYDROLZYING; CORROSION RESISTANCE Capote, Miguel Albert (US) 1999-11-16 US disclosed
WO-1999003597-A1 POLYMERIZABLE FLUXING AGENTS AND FLUXING ADHESIVE COMPOSITIONS THEREFROM AGUILA TECHNOLOGIES, INC. (US) 1999-01-28 WO disclosed