Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30360004 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL23516554 | 0.83 | MALT1 (0.40) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL23516703 | 0.83 | MEN1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL31020187 | 0.83 | MEN1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL19973967 | 0.80 | NPC1 (0.45) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL21633710 | 0.80 | KMT2A (0.48) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL26597479 | 0.79 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL20511865 | 0.79 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL26717793 | 0.78 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2MALT1 | |
| SCHEMBL26705986 | 0.78 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566002-B2 | Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2023-01-31 | — | — | US | disclosed |
| US-20210179557-A1 | SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179557-A1 | SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME | DHPS, HMBS, HAVCR2 | NPC1 667/4885RAB9A 863/4885MAPT 2409/4885 |
| US-11566002-B2 | Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same | DHPS, HMBS, HAVCR2 | NPC1 667/4885RAB9A 863/4885MAPT 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.