Sugi Predict

Sugi Predict / Compounds / SCHEMBL23516554

SCHEMBL23516554

SCHEMBL23516554

Cn1cnc(COC(=O)NC2CCn3c(C(=O)Nc4ccc(F)c(Cl)c4)ccc32)n1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MALT1 Q9UDY8 5/20 0.40
▸ MAOA P21397 2/20 0.38
▸ MAOB P27338 2/20 0.38
▸ LMNA P02545 2/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ THRB P10828 1/20 0.35
▸ KCNJ6 P48051 1/20 0.35
▸ KCNJ5 P48544 1/20 0.35
▸ KCNJ3 P48549 1/20 0.35
▸ CHRM3 P20309 1/20 0.35
▸ IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30360004 0.83 NPC1 (0.47) MALT1LMNANPC1MAPTRAB9A
SCHEMBL23516612 0.83 NPC1 (0.47) MALT1LMNANPC1MAPTRAB9A
SCHEMBL31020187 0.82 MEN1 (0.46) MALT1NPC1MAPTRAB9AALDH1A1
SCHEMBL23516703 0.82 MEN1 (0.46) MALT1NPC1MAPTRAB9AALDH1A1
SCHEMBL21777388 0.80 MAOA (0.38) MALT1MAOAMAOBLMNANPC1
SCHEMBL21777390 0.80 MAOA (0.38) MALT1MAOAMAOBLMNANPC1
SCHEMBL23496601 0.79 MAOA (0.37) MALT1MAOAMAOBLMNANPC1
SCHEMBL23516682 0.79 MAOA (0.39) MALT1MAOAMAOBLMNANPC1
SCHEMBL30359978 0.79 MAOA (0.39) MALT1MAOAMAOBLMNANPC1
SCHEMBL23516874 0.78 MAOA (0.37) MALT1MAOAMAOBLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US claimed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2023-01-31 — — US disclosed
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2021-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210179557-A1 SUBSTITUTED TETRAHYDROCYCLOPENTA[C]PYRROLES, SUBSTITUTED DIHYDROPYRROLIZINES, ANALOGUES THEREOF, AND METHODS USING SAME DHPS, HMBS, HAVCR2 MALT1 182/4885MAOA 3145/4885MAOB 2722/4885
US-11566002-B2 Substituted tetrahydrocyclopenta[C]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same DHPS, HMBS, HAVCR2 MALT1 182/4885MAOA 3145/4885MAOB 2722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.