Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 2/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 3/20 | 0.45 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.45 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.45 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.45 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352398 | 1.00 | HDAC3 (0.51) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL8722102 | 0.81 | HDAC3 (0.61) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL20869064 | 0.76 | CRHBP (0.54) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL2357262 | 0.75 | HDAC1 (0.60) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL2357257 | 0.75 | HDAC1 (0.60) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL10869967 | 0.75 | ALDH1A1 (0.60) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL7655294 | 0.73 | NPY1R (0.65) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL7935110 | 0.73 | HDAC1 (0.74) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL9987472 | 0.73 | HDAC1 (0.74) | HDAC3HDAC1HDAC4HDAC8HDAC6 | |
| SCHEMBL29456754 | 0.71 | EPHX1 (0.61) | HDAC3HDAC1HDAC4HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349245-A2 | TREATMENT OF RETROVIRAL RESERVOIRS EXPLOITING OXIDATIVE STRESS | Istituto Superiore di Sanità (IT) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010049182-A2 | TREATMENT OF RETROVIRAL RESERVOIRS EXPLOITING OXIDATIVE STRESS | ISTITUTO SUPERIORE DI SANITÁ (IT) | 2010-05-06 | — | — | WO | disclosed |