Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DGKZ | Q13574 | 6/20 | 0.33 |
| ▸ | DGKA | P23743 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | DGKI | O75912 | 1/20 | 0.30 |
| ▸ | DGKG | P49619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30766212 | 0.80 | ALDH1A1 (0.36) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL30616752 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL23293587 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL23802531 | 0.80 | ALDH1A1 (0.36) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL30910878 | 0.78 | ALDH1A1 (0.32) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL21831273 | 0.78 | ALDH1A1 (0.32) | ALDH1A1KDM4ELMNADGKZDGKA | |
| SCHEMBL23293492 | 0.75 | DGKA (0.44) | ALDH1A1KDM4EDGKZDGKAHSD17B10 | |
| SCHEMBL30616716 | 0.75 | DGKA (0.44) | ALDH1A1KDM4EDGKZDGKAHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL23293536 | 0.75 | DGKA (0.39) | DGKZDGKADGKIDGKGDGKK | |
| SCHEMBL30766166 | 0.72 | DGKA (0.35) | ALDH1A1KDM4ELMNADGKZDGKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964973-B2 | Substituted bicyclic compounds useful as T cell activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-23 | — | — | US | disclosed |
| US-20230086933-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY | 2023-03-23 | — | — | US | disclosed |
| EP-4081524-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | Bristol-Myers Squibb Company (US) | 2022-11-02 | — | — | EP | disclosed |
| WO-2021133752-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230086933-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKA, DGKG, DGKZ | ALDH1A1 4675/4885KDM4E 2895/4885LMNA 3783/4885 |
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKA, DGKZ, DGKK | ALDH1A1 4765/4885KDM4E 2817/4885LMNA 3445/4885 |
| US-11964973-B2 | Substituted bicyclic compounds useful as T cell activators | DGKA, DGKZ, DGKK | ALDH1A1 4765/4885KDM4E 2817/4885LMNA 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.