Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 7/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26098964 | 0.73 | SIGMAR1 (0.52) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL5757671 | 0.71 | CHRNB2 (0.53) | SIGMAR1CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4812347 | 0.70 | CHRNB2 (0.51) | SIGMAR1CHRM2CHRM1 | |
| SCHEMBL29297495 | 0.70 | PARP1 (0.45) | SIGMAR1 | |
| SCHEMBL4757486 | 0.69 | SIGMAR1 (0.47) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL22422495 | 0.69 | CHRNB2 (0.54) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL27969917 | 0.69 | CHRNB2 (0.47) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL13770498 | 0.69 | CXCR4 (0.49) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL29566635 | 0.69 | CHRNB2 (0.54) | SIGMAR1CXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL26665904 | 0.68 | SIGMAR1 (0.55) | SIGMAR1CXCR4MEN1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127273-A1 | 1 -((6-OXO-1,6-DIHYDROPYRIDAZIN-4-YL)METHYL)PIPERAZINE AND 1 -((6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)METHYL)PIPERAZINE DERIVATIVES AS PROLYL HYDROXYLASE, HIF-1 ALPHA AND PGK MODULATORS FOR USE IN TREATING INFLAMMATORY DISEASES, CANCER OR INFECTIONS | GB004, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127273-A1 | 1 -((6-OXO-1,6-DIHYDROPYRIDAZIN-4-YL)METHYL)PIPERAZINE AND 1 -((6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)METHYL)PIPERAZINE DERIVATIVES AS PROLYL HYDROXYLASE, HIF-1 ALPHA AND PGK MODULATORS FOR USE IN TREATING INFLAMMATORY DISEASES, CANCER OR INFECTIONS | GB004, INC. (US) | 2021-06-24 | — | — | WO | disclosed |