Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353014 | 1.00 | NFE2L2 (0.52) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL12175517 | 0.84 | VCP (0.53) | NFE2L2RAB9ATRPA1CYP1A2VCP | |
| SCHEMBL29110067 | 0.80 | APP (0.40) | NFE2L2VCP | |
| SCHEMBL29110068 | 0.80 | APP (0.40) | NFE2L2VCP | |
| SCHEMBL4953116 | 0.79 | NFE2L2 (0.52) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL4085705 | 0.79 | ALDH1A1 (0.57) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL2096112 | 0.79 | NFE2L2 (0.52) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL31560254 | 0.79 | NFE2L2 (0.52) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL14604964 | 0.79 | NFE2L2 (0.57) | NFE2L2PABPC1RAB9AEIF4HTRPA1 | |
| SCHEMBL4953119 | 0.79 | NFE2L2 (0.52) | NFE2L2PABPC1RAB9AEIF4HTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598412-B2 | Spiroindoline compounds for use as anthelminthics | INTERVET INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150057302-A1 | SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS | INTERVET INC. | 2015-02-26 | — | — | US | disclosed |
| EP-2531506-B1 | Spiroindoline compounds for use as anthelminthics | INTERVET INT BV (NL) | 2014-05-14 | — | — | EP | disclosed |
| EP-2531506-A1 | S PIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHI CS | Intervet International B.V. (NL) | 2012-12-12 | — | — | EP | disclosed |
| US-20120295931-A1 | SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS | INTERVET INC. | 2012-11-22 | — | — | US | disclosed |
| WO-2011095581-A1 | S PIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHI CS | INTERVET INTERNATIONAL B.V. (NL) | 2011-08-11 | — | — | WO | disclosed |
| US-6025310-A | RETAINING STABILITY FREE OF HYDROLYSIS FOR PROLONGED PERIOD OF TIME, COMPATIBLE WITH ORGANIC LUBRICANTS HAVING BENZENE RING AND PHOSPHAZINE RING | KUBOTA CORPORATION (JP) | 2000-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057302-A1 | SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS | PKD2, PKD1, PIR | NFE2L2 1785/4885PABPC1 4788/4885RAB9A 3172/4885 |
| US-20120295931-A1 | SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS | PKD2, PKD1, PIR | NFE2L2 1785/4885PABPC1 4788/4885RAB9A 3172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.