Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.44 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.94 |
| ▸ | TP53 | P04637 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 6/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20661275 | 0.97 | ALDH1A1 (0.89) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| SCHEMBL15246 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| SCHEMBL8468934 | 0.97 | ALDH1A1 (1.00) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL309541 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL971113 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Water SCHEMBL6142579 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Ammonia Solution, Strong SCHEMBL28575167 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| SCHEMBL4356329 | 0.94 | ALDH1A1 (0.94) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL9805647 | 0.92 | ALDH1A1 (0.89) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 | |
| Benzene SCHEMBL28123318 | 0.92 | ALDH1A1 (0.89) | ALDH1A1CYP3A4MAPK1TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680113-B2 | BMI-1 protein expression modulators | PTC THERAPEUTICS, INC. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS, INC. (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190239-A1 | BMI-1 PROTEIN EXPRESSION MODULATORS | BMI1, CREBBP, BAZ2A | ADRA2A 4808/4885ADRA2B 4630/4885ADRA2C 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.