Water

Water

SCHEMBL6142579

CN(C)c1ccc(N)cc1.O

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 2/20 0.47
ADRA2A known ✓ P08913 2/20 0.44
ADRA2B known ✓ P18089 2/20 0.44
ADRA2C known ✓ P18825 2/20 0.44
CHRM5 known ✓ P08912 1/20 0.43
ACHE known ✓ P22303 1/20 0.43
ALDH1A1 P00352 9/20 0.94
CYP3A4 P08684 4/20 0.94
TDP1 Q9NUW8 4/20 0.94
MAPK1 P28482 4/20 0.94
ALOX15 P16050 2/20 0.94
TP53 P04637 2/20 0.94
TSHR P16473 5/20 0.65
HSD17B10 Q99714 2/20 0.65
L3MBTL1 Q9Y468 2/20 0.50
PSMD14 O00487 1/20 0.50
RECQL P46063 1/20 0.50
GFER P55789 1/20 0.50
MAPT P10636 4/20 0.47
KMT2A Q03164 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8468934 0.97 ALDH1A1 (1.00) ALDH1A1CYP3A4TDP1MAPK1ALOX15
SCHEMBL15246 0.97 ALDH1A1 (1.00) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Hydrochloric Acid SCHEMBL971113 0.94 ALDH1A1 (0.94) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Ammonia Solution, Strong SCHEMBL28575167 0.94 ALDH1A1 (0.94) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Hydrochloric Acid SCHEMBL309541 0.94 ALDH1A1 (0.94) ALDH1A1CYP3A4TDP1MAPK1ALOX15
SCHEMBL4356329 0.94 ALDH1A1 (0.94) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Bromide SCHEMBL2353262 0.94 ALDH1A1 (0.94) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Bromide SCHEMBL20661275 0.92 ALDH1A1 (0.89) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Hydrochloric Acid SCHEMBL9805647 0.92 ALDH1A1 (0.89) ALDH1A1CYP3A4TDP1MAPK1ALOX15
Hydrochloric Acid SCHEMBL28273962 0.92 ALDH1A1 (0.89) ALDH1A1CYP3A4TDP1MAPK1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9902864-B2 Two-coat barrier system comprising polyurethane SUN CHEMICAL CORPORATION (US) 2018-02-27 US disclosed
EP-2691432-B1 A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE SUN CHEMICAL BV (NL) 2015-01-21 EP disclosed
US-20140212661-A1 TWO-COAST BARRIER SYSTEM COMPRISING POLYURETHANE SUN CHEMICAL CORPORATION (US) 2014-07-31 US disclosed
EP-2691432-A2 A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE Sun Chemical B.V. (NL) 2014-02-05 EP disclosed
WO-2012131362-A2 A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE SUN CHEMICAL B.V. (NL) 2012-10-04 WO disclosed
US-20050084686-A1 Gas barrier film FUTAMURA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2005-04-21 US disclosed
EP-1524110-A2 Gas barrier film Futamura Kagaku Kabushiki Kaisha (JP) 2005-04-20 EP disclosed