Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 13/20 | 0.43 |
| ▸ | INSR | P06213 | 12/20 | 0.43 |
| ▸ | IGF1R | P08069 | 12/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.41 |
| ▸ | STK10 | O94804 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | FES | P07332 | 2/20 | 0.41 |
| ▸ | YES1 | P07947 | 2/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
| ▸ | FER | P16591 | 2/20 | 0.41 |
| ▸ | LTK | P29376 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | FRK | P42685 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517468 | 0.91 | ALK (0.50) | ALKINSRIGF1REGFRPTK2 | |
| SCHEMBL10205071 | 0.90 | L3MBTL3 (0.46) | ALKINSRIGF1RPTK2L3MBTL3 | |
| SCHEMBL520521 | 0.87 | ALK (0.48) | ALKINSRIGF1REGFRPTK2 | |
| SCHEMBL519761 | 0.86 | ALDH1A1 (0.50) | ALKINSRIGF1REGFRPTK2 | |
| SCHEMBL29517345 | 0.86 | ALDH1A1 (0.50) | ALKINSRIGF1REGFRPTK2 | |
| SCHEMBL520836 | 0.86 | L3MBTL1 (0.57) | ALKINSRIGF1REGFRL3MBTL3 | |
| SCHEMBL10206202 | 0.86 | L3MBTL3 (0.53) | ALKINSRIGF1REGFRL3MBTL3 | |
| SCHEMBL30340719 | 0.86 | KHK (0.46) | KHK | |
| SCHEMBL309548 | 0.85 | L3MBTL1 (0.55) | ABL1L3MBTL3L3MBTL1HRH3 | |
| SCHEMBL13981638 | 0.85 | L3MBTL1 (0.55) | ABL1L3MBTL3L3MBTL1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114829352-B | Novel deuterated pyrimidine derivative and pharmaceutical composition containing same | 昂科比克斯有限公司 | 2024-05-31 | — | — | CN | disclosed |
| EP-4079730-A1 | NOVEL DEUTERIUM-SUBSTITUTED PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Oncobix Co., Ltd. (KR) | 2022-10-26 | — | — | EP | disclosed |
| CN-114829352-A | Novel deuterated pyrimidine derivative and pharmaceutical composition containing same | 昂科比克斯有限公司 | 2022-07-29 | — | — | CN | disclosed |
| WO-2021125758-A1 | NOVEL DEUTERIUM-SUBSTITUTED PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 온코빅스 | 2021-06-24 | — | — | WO | disclosed |