Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31028666 | 0.84 | KDM1A (0.36) | KDM1AKDM1BKCNH2ADRB2CYP1A2 | |
| SCHEMBL31394862 | 0.78 | KDM1A (0.32) | KDM1AKDM1BKCNH2CA2CYP1A2 | |
| SCHEMBL31413426 | 0.76 | TAAR1 (0.42) | KDM1AKDM1BKCNH2 | |
| SCHEMBL17466051 | 0.76 | KDM1A (0.32) | KDM1AKDM1BKCNH2ADRB2CYP1A2 | |
| SCHEMBL30707419 | 0.76 | KDM1A (0.32) | KDM1AKDM1BKCNH2ADRB2CYP1A2 | |
| SCHEMBL3368244 | 0.75 | CA2 (0.33) | KDM1AKDM1BKCNH2CA2CYP1A2 | |
| SCHEMBL13310106 | 0.75 | CYP1A2 (0.40) | KDM1AKDM1BCYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL31413389 | 0.74 | TAAR1 (0.41) | KDM1AKDM1BKCNH2 | |
| SCHEMBL31424538 | 0.74 | CXCL8 (0.36) | KDM1AKDM1BKCNH2 | |
| SCHEMBL30886492 | 0.74 | KIF11 (0.34) | KDM1AKDM1BKCNH2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076459-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |