Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18531440 | 0.87 | TDO2 (0.42) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL20247288 | 0.81 | ATM (0.43) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL31434883 | 0.81 | ATM (0.43) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL17466058 | 0.80 | MAPT (0.42) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL15577394 | 0.79 | CYP1A2 (0.53) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL29706788 | 0.79 | CYP1A2 (0.53) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL16017314 | 0.79 | ALDH1A1 (0.43) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL30886409 | 0.78 | TDO2 (0.39) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL535368 | 0.78 | TDO2 (0.36) | TDO2TDP1ATMSNCAMAPT | |
| SCHEMBL6630381 | 0.77 | ATM (0.42) | TDO2TDP1ATMSNCAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076459-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021126728-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |