Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 12/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19667418 | 0.79 | ADCY5 (0.39) | ADCY5 | |
| SCHEMBL19667419 | 0.78 | ADCY5 (0.40) | ADCY5 | |
| SCHEMBL31123772 | 0.78 | PRMT5 (0.42) | NNMTSLC22A12 | |
| SCHEMBL23692929 | 0.78 | PRMT5 (0.42) | NNMTSLC22A12 | |
| SCHEMBL7114998 | 0.75 | PRMT5 (0.38) | NNMTSLC22A12ADCY5 | |
| SCHEMBL19667277 | 0.74 | PRMT5 (0.37) | ADCY5 | |
| SCHEMBL21129932 | 0.74 | NNMT (0.39) | NNMTSLC22A12 | |
| SCHEMBL21129998 | 0.72 | SLC22A12 (0.39) | NNMTSLC22A12 | |
| SCHEMBL19684699 | 0.72 | PRMT5 (0.39) | — | |
| SCHEMBL21130182 | 0.71 | PIP4K2A (0.40) | NNMTSLC22A12ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |