SCHEMBL23535979

SCHEMBL23535979

CN(C)S(=O)(=O)c1ccc(C(C)(C)Nc2ccccc2N2CCN(Cc3ccccc3)CC2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 2/20 0.45
ALDH1A1 P00352 3/20 0.45
TSHR P16473 1/20 0.45
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
KDM4E B2RXH2 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
ALOX15 P16050 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HTR6 P50406 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29931875 1.00 CXCR4 (0.45) CXCR4ALDH1A1TSHRMEN1KMT2A
SCHEMBL29931755 0.76 CXCR4 (0.47) CXCR4ALDH1A1TSHRKDM4ECYP1A2
SCHEMBL29932087 0.76 CXCR4 (0.49) CXCR4ALDH1A1TSHRKDM4ECYP1A2
SCHEMBL23536182 0.76 CXCR4 (0.49) CXCR4ALDH1A1TSHRKDM4ECYP1A2
SCHEMBL23536063 0.74 CXCR4 (0.47) CXCR4ALDH1A1TSHRMEN1KMT2A
SCHEMBL4513143 0.72 MAPT (0.52) TSHRMAPTNPSR1TDP1L3MBTL1
SCHEMBL30232800 0.71 MCOLN3 (0.53) ALDH1A1TSHRKMT2AKDM4ESMN1; SMN2
SCHEMBL23536292 0.71 L3MBTL1 (0.45) ALDH1A1TSHRSMN1; SMN2LMNAL3MBTL1
SCHEMBL23536025 0.69 ALDH1A1 (0.62) ALDH1A1TSHRMEN1KMT2AKDM4E
SCHEMBL29931868 0.69 ALDH1A1 (0.62) ALDH1A1TSHRMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021127337-A1 TRPML MODULATORS CASMA THERAPEUTICS, INC. (US) 2021-06-24 WO disclosed