Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686126 | 0.87 | HIF1A (0.45) | OGAHIF1AEPAS1TRPM8ALDH1A1 | |
| SCHEMBL30232618 | 0.84 | CA2 (0.45) | OGAHIF1AEPAS1TRPM8KDM4E | |
| SCHEMBL30511906 | 0.75 | PKM (0.58) | MAPTPKMPKLR | |
| SCHEMBL639690 | 0.75 | PKM (0.58) | MAPTPKMPKLR | |
| SCHEMBL19029897 | 0.74 | MAOB (0.39) | OGAALDH1A1KDM4EMAPTPKM | |
| Lithium Ion SCHEMBL23536599 | 0.73 | PDE4B (0.38) | OGAHIF1AEPAS1ALDH1A1KDM4E | |
| SCHEMBL8423372 | 0.72 | PKM (0.36) | HIF1AEPAS1PKMPKLR | |
| SCHEMBL12180466 | 0.72 | KDM4E (0.38) | OGAALDH1A1KDM4EMAPTIRAK4 | |
| SCHEMBL10689616 | 0.71 | CA2 (0.45) | HIF1AEPAS1KDM4EMAPTPKM | |
| SCHEMBL20511231 | 0.71 | KDM4E (0.37) | KDM4EMAPTPKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |