Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324666 | 0.89 | FFAR4 (0.45) | GRM5KMT2AMEN1EPHX2PHGDH | |
| SCHEMBL29931954 | 0.80 | USP30 (0.49) | GRM5KMT2AMEN1 | |
| SCHEMBL23535945 | 0.80 | USP30 (0.49) | GRM5KMT2AMEN1 | |
| SCHEMBL1394565 | 0.78 | SCD (0.48) | GRM5NOTUMALDH1A1NPC1 | |
| Trifluoroacetic Acid SCHEMBL29931781 | 0.77 | SLC22A12 (0.37) | GRM5KMT2AMEN1NOTUMCCR2 | |
| SCHEMBL29948599 | 0.77 | MAPT (0.43) | GRM5KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL23536467 | 0.75 | DRD4 (0.36) | GRM5KMT2AMEN1PHGDHALDH1A1 | |
| SCHEMBL29772849 | 0.74 | CYP11B2 (0.48) | GRM5KMT2AMEN1 | |
| SCHEMBL23536130 | 0.73 | ALDH1A1 (0.42) | KMT2AMEN1PHGDHALDH1A1 | |
| SCHEMBL29932056 | 0.73 | ALDH1A1 (0.42) | KMT2AMEN1PHGDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |