Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932021 | 0.82 | PROKR1 (0.39) | GRM2DRD4PROKR1FPR2PHGDH | |
| SCHEMBL23536493 | 0.81 | PHGDH (0.42) | PROKR1FPR2POLBPHGDHHTT | |
| SCHEMBL29932124 | 0.81 | PHGDH (0.42) | PROKR1FPR2POLBPHGDHHTT | |
| SCHEMBL23536504 | 0.79 | DRD4 (0.42) | GRM2DRD4POLBPHGDHDPP4 | |
| SCHEMBL29931890 | 0.79 | DRD4 (0.42) | GRM2DRD4POLBPHGDHDPP4 | |
| SCHEMBL23536606 | 0.77 | POLB (0.45) | GRM2DRD4PROKR1FPR2POLB | |
| SCHEMBL29932044 | 0.77 | POLB (0.45) | GRM2DRD4PROKR1FPR2POLB | |
| SCHEMBL30232543 | 0.73 | PHGDH (0.40) | GRM2DRD4PHGDHDPP4DPP8 | |
| SCHEMBL30232821 | 0.73 | PHGDH (0.40) | GRM2DRD4PROKR1FPR2PHGDH | |
| SCHEMBL23536333 | 0.72 | SSTR2 (0.45) | GRM2DRD4POLBPHGDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |