Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.37 |
| ▸ | FPR2 | P25090 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932044 | 1.00 | POLB (0.45) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL23536271 | 0.80 | RPS6KB1 (0.45) | POLBDRD4GRM2PHGDHALDH1A1 | |
| SCHEMBL29932053 | 0.80 | RPS6KB1 (0.45) | POLBDRD4GRM2PHGDHALDH1A1 | |
| SCHEMBL23536198 | 0.77 | GRM2 (0.40) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL29931958 | 0.77 | DRD4 (0.38) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL23536237 | 0.77 | DRD4 (0.38) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL29931770 | 0.76 | DRD4 (0.47) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL23536253 | 0.76 | DRD4 (0.47) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL23536434 | 0.76 | DRD4 (0.47) | POLBDRD4GRM2PHGDHADORA2A | |
| SCHEMBL29931887 | 0.76 | DRD4 (0.47) | POLBDRD4GRM2PHGDHADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |