Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932080 | 1.00 | HTT (0.49) | HTTKMT2ACTSBHSD11B1ALDH1A1 | |
| SCHEMBL23536119 | 0.79 | GAA (0.51) | KMT2AALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL2206983 | 0.76 | CTSB (0.68) | HTTKMT2ACTSBALDH1A1MAPT | |
| SCHEMBL30779614 | 0.76 | CTSB (0.68) | HTTKMT2ACTSBALDH1A1MAPT | |
| SCHEMBL3435490 | 0.75 | CTSB (0.52) | HTTKMT2ACTSBALDH1A1MAPT | |
| SCHEMBL23043784 | 0.74 | HTT (0.54) | HTTKMT2ACTSBHSD11B1ALDH1A1 | |
| SCHEMBL1274938 | 0.74 | HTT (0.73) | HTTKMT2ACTSBHSD11B1ALDH1A1 | |
| SCHEMBL23536471 | 0.74 | HTT (0.48) | HTTKMT2ACTSBALDH1A1MAPT | |
| SCHEMBL29948611 | 0.74 | HTT (0.48) | HTTKMT2ACTSBALDH1A1MAPT | |
| SCHEMBL3436179 | 0.74 | KMT2A (0.56) | HTTKMT2AHSD11B1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |