Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536471 | 1.00 | HTT (0.48) | HTTKMT2ADRD4HTR1ANAMPT | |
| SCHEMBL23536225 | 0.84 | CTSB (0.49) | HTTKMT2AHTR1AALDH1A1LMNA | |
| SCHEMBL29931897 | 0.84 | CTSB (0.49) | HTTKMT2AHTR1AALDH1A1LMNA | |
| SCHEMBL28867446 | 0.81 | HTR1A (0.48) | HTTKMT2ADRD4HTR1AMITF | |
| SCHEMBL28867516 | 0.80 | MEN1 (0.47) | KMT2AHTR1ANAMPTDRD2 | |
| SCHEMBL1274938 | 0.77 | HTT (0.73) | HTTKMT2ADRD4HTR1AMITF | |
| SCHEMBL30779614 | 0.75 | CTSB (0.68) | HTTKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL2206983 | 0.75 | CTSB (0.68) | HTTKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL23536201 | 0.74 | HTT (0.49) | HTTKMT2AMITFALDH1A1LMNA | |
| SCHEMBL29932080 | 0.74 | HTT (0.49) | HTTKMT2AMITFALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |