Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.51 |
| ▸ | HTR3A | P46098 | 19/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932303 | 1.00 | HTR1A (0.51) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23555180 | 0.85 | OPRL1 (0.38) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29932077 | 0.85 | HTR1A (0.42) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23535984 | 0.85 | HTR1A (0.42) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29932038 | 0.82 | HTR1A (0.43) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29932148 | 0.82 | OPRL1 (0.38) | CYP3A4 | |
| SCHEMBL23536392 | 0.82 | OPRL1 (0.38) | CYP3A4 | |
| SCHEMBL29931984 | 0.78 | CYP1A2 (0.39) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23536340 | 0.77 | OPRL1 (0.37) | — | |
| SCHEMBL23536112 | 0.77 | POLB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |