Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932148 | 1.00 | OPRL1 (0.38) | OPRL1GRM2MAPTPOLBTP53 | |
| SCHEMBL29932103 | 0.85 | TSHR (0.38) | OPRL1GRM2MAPTTP53KMT2A | |
| SCHEMBL23536136 | 0.85 | TSHR (0.38) | OPRL1GRM2MAPTTP53KMT2A | |
| SCHEMBL21261310 | 0.85 | MAPT (0.47) | GRM2MAPTPOLBTP53DRD4 | |
| SCHEMBL29932033 | 0.83 | MAPT (0.34) | OPRL1MAPTPOLBTP53MEN1 | |
| SCHEMBL23536205 | 0.82 | HTR1A (0.51) | CYP3A4 | |
| SCHEMBL29932303 | 0.82 | HTR1A (0.51) | CYP3A4 | |
| SCHEMBL23536030 | 0.81 | GRM2 (0.43) | OPRL1GRM2KMT2AGPBAR1 | |
| SCHEMBL23536165 | 0.80 | TSHR (0.43) | OPRL1GRM2MAPTPOLBTP53 | |
| SCHEMBL23536038 | 0.80 | OPRL1 (0.37) | OPRL1GRM2DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |