Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932070 | 1.00 | HRH4 (0.47) | HRH4MAPTMEN1KMT2ALMNA | |
| SCHEMBL29931841 | 0.79 | HRH4 (0.43) | HRH4MAPTMEN1KMT2ALMNA | |
| SCHEMBL23536446 | 0.79 | HRH4 (0.43) | HRH4MAPTMEN1KMT2ALMNA | |
| SCHEMBL29931890 | 0.75 | DRD4 (0.42) | HRH4LMNAALDH1A1POLB | |
| SCHEMBL23536504 | 0.75 | DRD4 (0.42) | HRH4LMNAALDH1A1POLB | |
| SCHEMBL29932027 | 0.71 | ALDH1A1 (0.41) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL23536545 | 0.65 | ALDH1A1 (0.52) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL23536198 | 0.65 | GRM2 (0.40) | HRH4LMNAALDH1A1POLB | |
| SCHEMBL31342403 | 0.64 | MAPK1 (0.46) | MAPK1P2RX3 | |
| SCHEMBL31342401 | 0.64 | MAPK1 (0.46) | MAPK1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |