Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931770 | 1.00 | DRD4 (0.47) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL23536434 | 0.80 | DRD4 (0.47) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL29931887 | 0.80 | DRD4 (0.47) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL29932044 | 0.76 | POLB (0.45) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL23536606 | 0.76 | POLB (0.45) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL8275465 | 0.76 | POLB (0.65) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL23536504 | 0.73 | DRD4 (0.42) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL29931890 | 0.73 | DRD4 (0.42) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL23536198 | 0.71 | GRM2 (0.40) | DRD4GRM2POLBPHGDHALDH1A1 | |
| SCHEMBL21261239 | 0.71 | POLB (0.54) | DRD4GRM2POLBPHGDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |