Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043637 | 0.85 | KMT2A (0.55) | RECQLMCOLN2KMT2AMEN1MAPT | |
| SCHEMBL23536016 | 0.81 | KMT2A (0.47) | KMT2AMEN1MAPTMAPK1L3MBTL1 | |
| SCHEMBL29948512 | 0.80 | MCOLN2 (0.56) | MCOLN2L3MBTL1LMNAALDH1A1KDM4E | |
| SCHEMBL23057224 | 0.80 | MCOLN2 (0.76) | RECQLMCOLN2MAPTL3MBTL1POLB | |
| SCHEMBL14804205 | 0.79 | KDM4E (0.64) | KMT2AMEN1MAPTMAPK1L3MBTL1 | |
| SCHEMBL30108668 | 0.77 | KMT2A (0.46) | RECQLMCOLN2KMT2AMEN1MAPT | |
| SCHEMBL29932019 | 0.76 | MCOLN2 (0.49) | MCOLN2KMT2AMAPTL3MBTL1LMNA | |
| SCHEMBL23536283 | 0.76 | MCOLN2 (0.44) | RECQLMCOLN2KMT2AMEN1MAPT | |
| SCHEMBL29947135 | 0.76 | MCOLN2 (0.48) | MCOLN2KMT2AMAPTMAPK1L3MBTL1 | |
| SCHEMBL29948535 | 0.76 | MCOLN2 (0.48) | MCOLN2KMT2AMEN1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |