Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043638 | 0.86 | ALDH1A1 (0.48) | ALDH1A1GAAHTTKDM4ELMNA | |
| SCHEMBL23536018 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAL3MBTL1KMT2A | |
| SCHEMBL23043612 | 0.78 | ALDH1A1 (0.52) | MCOLN2ALDH1A1GAAHTTKDM4E | |
| SCHEMBL23536282 | 0.76 | RECQL (0.54) | MCOLN2ALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL23536098 | 0.71 | TP53 (0.44) | ALDH1A1KDM4EHPGDL3MBTL1TP53 | |
| SCHEMBL23536173 | 0.71 | TP53 (0.44) | ALDH1A1HTTKDM4EHPGDL3MBTL1 | |
| SCHEMBL23536231 | 0.70 | POLB (0.59) | ALDH1A1KMT2ATP53SMN1; SMN2MAPT | |
| SCHEMBL29948512 | 0.69 | MCOLN2 (0.56) | MCOLN2ALDH1A1GAAHTTKDM4E | |
| SCHEMBL23043625 | 0.69 | ALDH1A1 (0.52) | MCOLN2ALDH1A1GAAHTTKDM4E | |
| SCHEMBL23536308 | 0.69 | TP53 (0.42) | ALDH1A1KDM4EHPGDL3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |