Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536010 | 0.89 | KDM1A (0.34) | KDM1ACYP2A13KDM4EHTTNPC1 | |
| SCHEMBL23536061 | 0.86 | KDM1A (0.33) | KDM1ACYP2A13KDM4EHTT | |
| SCHEMBL23536046 | 0.82 | ALDH1A1 (0.42) | KDM4EHTTPTPN11RAB9APOLB | |
| SCHEMBL29932205 | 0.82 | ALDH1A1 (0.42) | KDM4EHTTPTPN11RAB9APOLB | |
| SCHEMBL23536058 | 0.79 | CYP2A13 (0.34) | CYP2A13KDM4EHTTNPC1RAB9A | |
| SCHEMBL23535973 | 0.79 | CYP2A13 (0.34) | CYP2A13KDM4EHTTNPC1RAB9A | |
| SCHEMBL23536077 | 0.77 | BPTF (0.35) | CYP2A13KDM4EHTT | |
| SCHEMBL29931901 | 0.74 | MCOLN2 (0.47) | KDM4E | |
| SCHEMBL28867487 | 0.71 | MEN1 (0.33) | NPC1RAB9A | |
| SCHEMBL28867476 | 0.71 | ALDH1A1 (0.42) | KDM4EHTTRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |