Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932092 | 1.00 | LMNA (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29932039 | 0.88 | POLB (0.38) | SMN1; SMN2PROKR1OPRL1FPR2ALDH1A1 | |
| SCHEMBL29932243 | 0.83 | LMNA (0.38) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536043 | 0.83 | LMNA (0.38) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536117 | 0.78 | POLB (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29931921 | 0.78 | POLB (0.41) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23535959 | 0.76 | SMN1; SMN2 (0.42) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL29948492 | 0.76 | SMN1; SMN2 (0.42) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23535984 | 0.76 | HTR1A (0.42) | LMNATP53GAAHTTSMN1; SMN2 | |
| SCHEMBL23536124 | 0.76 | TSHR (0.39) | LMNATP53GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |