Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931921 | 1.00 | POLB (0.41) | POLBCNR1GPR55SMN1; SMN2LMNA | |
| SCHEMBL29931915 | 0.90 | ALDH1A1 (0.39) | SMN1; SMN2LMNAGAAHTTTP53 | |
| SCHEMBL29948574 | 0.89 | POLB (0.42) | POLBCNR1LMNAHTTHTR6 | |
| SCHEMBL23536112 | 0.89 | POLB (0.42) | POLBCNR1LMNAHTTHTR6 | |
| SCHEMBL29948492 | 0.88 | SMN1; SMN2 (0.42) | POLBCNR1GPR55SMN1; SMN2LMNA | |
| SCHEMBL23535959 | 0.88 | SMN1; SMN2 (0.42) | POLBCNR1GPR55SMN1; SMN2LMNA | |
| SCHEMBL23536124 | 0.84 | TSHR (0.39) | CNR1GPR55SMN1; SMN2LMNAGAA | |
| SCHEMBL23535984 | 0.84 | HTR1A (0.42) | CNR1GPR55SMN1; SMN2LMNAGAA | |
| SCHEMBL23536363 | 0.84 | MCOLN2 (0.48) | POLBSMN1; SMN2LMNAGAAHTT | |
| SCHEMBL29931867 | 0.84 | TSHR (0.39) | CNR1GPR55SMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230104936-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | POLB 4797/4885CNR1 155/4885GPR55 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.