Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932060 | 1.00 | ALDH1A1 (0.39) | ALDH1A1LMNAKDM4EHTTDRD4 | |
| SCHEMBL29931935 | 0.81 | ALDH1A1 (0.44) | ALDH1A1LMNAHTTMAPTMAPK1 | |
| SCHEMBL23536527 | 0.81 | ALDH1A1 (0.44) | ALDH1A1LMNAHTTMAPTMAPK1 | |
| SCHEMBL21261239 | 0.74 | POLB (0.54) | ALDH1A1LMNAKDM4EHTTDRD4 | |
| SCHEMBL29931958 | 0.74 | DRD4 (0.38) | ALDH1A1DRD4GRM2POLBTRPV1 | |
| SCHEMBL23536237 | 0.74 | DRD4 (0.38) | ALDH1A1DRD4GRM2POLBTRPV1 | |
| SCHEMBL29931990 | 0.72 | DRD4 (0.39) | ALDH1A1LMNADRD4GRM2MAPT | |
| SCHEMBL23536130 | 0.70 | ALDH1A1 (0.42) | ALDH1A1LMNAKDM4EHTTDRD4 | |
| SCHEMBL29932056 | 0.70 | ALDH1A1 (0.42) | ALDH1A1LMNAKDM4EHTTDRD4 | |
| SCHEMBL24628435 | 0.68 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EHTTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |