Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931958 | 1.00 | DRD4 (0.38) | DRD4GRM2PHGDHPROKR1POLB | |
| SCHEMBL23536369 | 0.83 | ALDH1A1 (0.38) | DRD4GRM2PHGDHPROKR1ALDH1A1 | |
| SCHEMBL29932049 | 0.79 | PHGDH (0.39) | DRD4GRM2PHGDHPROKR1TRPV1 | |
| SCHEMBL23536190 | 0.79 | PHGDH (0.39) | DRD4GRM2PHGDHPROKR1TRPV1 | |
| SCHEMBL29932026 | 0.78 | SIGMAR1 (0.36) | DRD4GRM2PHGDHPROKR1FPR2 | |
| SCHEMBL23536606 | 0.77 | POLB (0.45) | DRD4GRM2PHGDHPROKR1POLB | |
| SCHEMBL29932044 | 0.77 | POLB (0.45) | DRD4GRM2PHGDHPROKR1POLB | |
| SCHEMBL29932109 | 0.76 | MAPT (0.37) | PROKR1ALDH1A1HTR6DRD2 | |
| SCHEMBL29931836 | 0.74 | GAA (0.34) | DRD4GRM2PROKR1ALDH1A1FPR2 | |
| SCHEMBL23536396 | 0.74 | ALDH1A1 (0.39) | DRD4GRM2POLBALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |