Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.50 |
| ▸ | GRM5 | P41594 | 9/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536398 | 0.83 | SHMT2 (0.35) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL25129377 | 0.78 | BTK (0.51) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL29910537 | 0.77 | PDK4 (0.51) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL18081229 | 0.77 | PDK4 (0.51) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL23411394 | 0.77 | GRM1 (0.53) | PDK4GRM1GRM5HTR6NAMPT | |
| SCHEMBL83700 | 0.77 | PDK4 (0.68) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL30061046 | 0.77 | PDK4 (0.68) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL31053191 | 0.77 | GRM1 (0.58) | PDK4GRM1GRM5HTR6TNK2 | |
| SCHEMBL22820579 | 0.76 | BTK (0.51) | PDK4GRM1GRM5HTR6BTK | |
| SCHEMBL30269890 | 0.76 | BTK (0.60) | PDK4GRM1GRM5HTR6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |