Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | QDPR | P09417 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536458 | 0.83 | PDK4 (0.53) | HTR6BTKGRM5GRM1NAMPT | |
| SCHEMBL28693846 | 0.74 | EIF2AK3 (0.44) | — | |
| SCHEMBL28672701 | 0.73 | JMJD6 (0.41) | SHMT2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25171676 | 0.73 | NAMPT (0.44) | SHMT2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28565843 | 0.72 | CNR1 (0.37) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2269990 | 0.72 | USP2 (0.35) | QDPRATR | |
| SCHEMBL1937547 | 0.71 | GABRP (0.46) | ALDH1A1SMN1; SMN2QDPRBTK | |
| SCHEMBL28365554 | 0.71 | BTK (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL18186201 | 0.70 | MAPT (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL13737830 | 0.70 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |