Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535998 | 0.84 | MAOB (0.37) | MAOBCNR2KMT2AMEN1RAB9A | |
| SCHEMBL23536026 | 0.82 | MAOB (0.37) | MAOBCNR2ALDH1A1TRPV3 | |
| SCHEMBL23536171 | 0.82 | MAOB (0.37) | MAOBCNR2KMT2AMEN1RAB9A | |
| SCHEMBL29932063 | 0.77 | KMT2A (0.39) | P2RX7KMT2ARAB9AALDH1A1TSHR | |
| SCHEMBL28867512 | 0.74 | MC4R (0.35) | CNR2TRPV3 | |
| SCHEMBL28867505 | 0.74 | MC4R (0.38) | TRPV3 | |
| SCHEMBL28867513 | 0.74 | MC4R (0.35) | CNR2TRPV3 | |
| SCHEMBL28867506 | 0.74 | MC4R (0.38) | TRPV3 | |
| SCHEMBL23925319 | 0.73 | ALDH1A1 (0.43) | KMT2AMEN1RAB9AALDH1A1KDM4E | |
| SCHEMBL7915890 | 0.72 | HTR1A (0.37) | MAOBKMT2AHTR1ADRD2TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |