Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 3/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536026 | 0.85 | MAOB (0.37) | MAOBTRPV3CNR2GUCY1B2GUCY1A2 | |
| SCHEMBL23536505 | 0.82 | MAOB (0.39) | MAOBTRPV3CNR2ALDH1A1MEN1 | |
| SCHEMBL23535998 | 0.78 | MAOB (0.37) | MAOBCNR2GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL23535948 | 0.78 | ICMT (0.32) | — | |
| SCHEMBL28867506 | 0.75 | MC4R (0.38) | TRPV3MC4RMC5RMC3R | |
| SCHEMBL28867512 | 0.75 | MC4R (0.35) | TRPV3CNR2MC4RMC5RMC3R | |
| SCHEMBL28867505 | 0.75 | MC4R (0.38) | TRPV3MC4RMC5RMC3R | |
| SCHEMBL28867513 | 0.75 | MC4R (0.35) | TRPV3CNR2MC4RMC5RMC3R | |
| SCHEMBL29932063 | 0.72 | KMT2A (0.39) | ALDH1A1RAB9AKMT2A | |
| SCHEMBL23925319 | 0.71 | ALDH1A1 (0.43) | ALDH1A1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |