Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NPY2R | P49146 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19418973 | 0.83 | USP2 (0.62) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL23535932 | 0.81 | ENPP2 (0.53) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL17552184 | 0.81 | MEN1 (0.69) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL21261350 | 0.80 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL22305400 | 0.80 | TSHR (0.80) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11715149 | 0.80 | TSHR (0.80) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL29772909 | 0.77 | L3MBTL1 (0.55) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL24628361 | 0.77 | L3MBTL1 (0.55) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL946774 | 0.77 | GRM5 (0.61) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL16276065 | 0.77 | MAPT (0.59) | TSHRSMN1; SMN2ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |