Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21261350 | 0.88 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL29772909 | 0.84 | L3MBTL1 (0.55) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL24628361 | 0.84 | L3MBTL1 (0.55) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL23536551 | 0.81 | TSHR (0.66) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8048603 | 0.80 | ALDH1A1 (0.61) | ENPP2ALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL11102561 | 0.78 | ALDH1A1 (0.57) | ENPP2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL29772902 | 0.77 | DRD4 (0.49) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL21261309 | 0.77 | DRD4 (0.49) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL21261239 | 0.77 | POLB (0.54) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL21261307 | 0.76 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |