Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.46 |
| ▸ | GLP1R | P43220 | 5/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29902223 | 0.90 | BCHE (0.45) | LMNASMN1; SMN2SIRT2SIRT1CAPN1 | |
| SCHEMBL29902250 | 0.90 | BCHE (0.45) | LMNASMN1; SMN2SIRT2SIRT1CAPN1 | |
| SCHEMBL23538096 | 0.90 | BCHE (0.45) | LMNASMN1; SMN2SIRT2SIRT1CAPN1 | |
| SCHEMBL29467642 | 0.89 | LMNA (0.54) | LMNASMN1; SMN2SIRT2SIRT1FOLH1 | |
| SCHEMBL29902227 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2SIRT2SIRT1CAPN1 | |
| SCHEMBL29902259 | 0.88 | LMNA (0.47) | LMNASMN1; SMN2SIRT2SIRT1CAPN1 | |
| SCHEMBL31631396 | 0.87 | FOLH1 (0.57) | LMNASMN1; SMN2SIRT2SIRT1FOLH1 | |
| SCHEMBL15382100 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2SIRT2SIRT1FOLH1 | |
| SCHEMBL29336444 | 0.83 | LMNA (0.54) | LMNASMN1; SMN2SIRT2SIRT1FOLH1 | |
| SCHEMBL23451317 | 0.83 | SIRT2 (0.58) | SIRT2SIRT1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127460-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |