Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29902227 | 1.00 | LMNA (0.47) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL29902223 | 0.98 | BCHE (0.45) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL29902250 | 0.98 | BCHE (0.45) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL23538096 | 0.98 | BCHE (0.45) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL29467688 | 0.92 | LMNA (0.49) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL29902219 | 0.91 | LMNA (0.47) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL30638287 | 0.88 | LMNA (0.52) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL19509744 | 0.88 | LMNA (0.52) | LMNASMN1; SMN2BCHEACHESYK | |
| SCHEMBL23537876 | 0.88 | LMNA (0.49) | LMNASMN1; SMN2BCHEACHESIRT2 | |
| SCHEMBL15382100 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2BCHEACHESIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076492-A1 | PCSK9 ANTAGONIST COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |