SCHEMBL2353807

SCHEMBL2353807

O=C(NCc1ccccc1)C1=CC=CNC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.46
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
TSHR P16473 1/20 0.45
HPGDS O60760 1/20 0.44
HPGD P15428 3/20 0.44
GAA P10253 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 1/20 0.44
MC4R P32245 1/20 0.44
RAB9A P51151 1/20 0.44
HSD17B10 Q99714 1/20 0.44
MMP13 P45452 1/20 0.43
METAP2 P50579 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA4 P43681 1/20 0.43
APEX1 P27695 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31490156 0.81 EPHX2 (0.50) HPGDGAALMNAHSD17B10ALDH1A1
SCHEMBL1397072 0.73 KMT2A (0.49) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL6400161 0.71 KMT2A (0.54) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL2205418 0.71 KMT2A (0.50) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL2012615 0.71 HPGD (0.47) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL5794439 0.70 SMN1; SMN2 (0.49) KMT2AGAARAB9AALDH1A1
SCHEMBL11901003 0.68 KMT2A (0.89) KMT2AHDAC2HDAC8HDAC6TSHR
SCHEMBL11900090 0.68 HDAC6 (0.85) HDAC2HDAC8HDAC6TSHRHPGD
SCHEMBL457082 0.68 HDAC6 (0.79) HDAC2HDAC8HDAC6HPGDGAA
SCHEMBL31680569 0.68 KMT2A (0.89) KMT2AHDAC2HDAC8HDAC6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349328-A1 METHODS FOR THE TREATMENT OF CANCER LUDWIG INSTITUTE FOR CANCER RESEARCH (US) 2011-08-03 EP claimed
EP-2349328-A1 METHODS FOR THE TREATMENT OF CANCER LUDWIG INSTITUTE FOR CANCER RESEARCH (US) 2011-08-03 EP disclosed
WO-2010039248-A1 METHODS FOR THE TREATMENT OF CANCER LUDWIG INSTITUTE FOR CANCER RESEARCH (US) 2010-04-08 WO disclosed