Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236699 | 0.82 | HPGD (0.53) | HPGDSMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL2353807 | 0.71 | KMT2A (0.46) | HPGDALDH1A1MMP13KMT2AHDAC2 | |
| SCHEMBL30865487 | 0.69 | HPGD (0.77) | HPGDSMN1; SMN2ALDH1A1TP53KMT2A | |
| SCHEMBL11900090 | 0.68 | HDAC6 (0.85) | HPGDTP53MMP13HDAC2HDAC8 | |
| SCHEMBL11901003 | 0.68 | KMT2A (0.89) | HPGDTP53KMT2AHDAC2HDAC8 | |
| SCHEMBL457082 | 0.68 | HDAC6 (0.79) | HPGDALDH1A1TP53HDAC2HDAC8 | |
| SCHEMBL31680569 | 0.68 | KMT2A (0.89) | HPGDTP53KMT2AHDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL6501979 | 0.68 | HDAC6 (0.49) | HPGDTP53KMT2AHDAC2HDAC8 | |
| SCHEMBL5812651 | 0.67 | RAB9A (0.56) | HPGDSMN1; SMN2ALDH1A1TP53MMP13 | |
| Hydrochloric Acid SCHEMBL3757721 | 0.67 | HDAC6 (0.76) | HPGDALDH1A1TP53HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| EP-1537090-A1 | CHROMONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014880-A1 | CHROMONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |