Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.79 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032454 | 0.81 | L3MBTL1 (0.72) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL24654650 | 0.81 | L3MBTL1 (0.78) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4124368 | 0.79 | L3MBTL1 (0.75) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL23565515 | 0.79 | RAB9A (0.53) | L3MBTL1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL20639917 | 0.79 | L3MBTL1 (0.49) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL25160800 | 0.79 | RAB9A (0.68) | L3MBTL1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL2632202 | 0.79 | L3MBTL1 (0.68) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL27596585 | 0.78 | L3MBTL1 (0.72) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL17151535 | 0.78 | L3MBTL1 (0.72) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL27578720 | 0.78 | L3MBTL1 (0.77) | L3MBTL1PTK2RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127459-A1 | GPR139 RECEPTOR MODULATORS | BLACKTHORN THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |