SCHEMBL4124368

SCHEMBL4124368

O=C(O)Nc1ccc(Cl)cn1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.75
PTK2 Q05397 1/20 0.70
RAB9A P51151 10/20 0.63
SMN1; SMN2 Q16637 5/20 0.63
TSHR P16473 3/20 0.63
TP53 P04637 1/20 0.63
NFKB1 P19838 1/20 0.63
NFKB2 Q00653 1/20 0.63
RELA Q04206 1/20 0.63
TDP1 Q9NUW8 2/20 0.62
BRD4 O60885 1/20 0.60
NPC1 O15118 5/20 0.59
HTT P42858 2/20 0.59
ALOX15 P16050 1/20 0.59
LMNA P02545 2/20 0.58
NPSR1 Q6W5P4 1/20 0.58
STAT1 P42224 1/20 0.58
KMT2A Q03164 2/20 0.57
MAPT P10636 1/20 0.57
GLA P06280 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24654650 0.86 L3MBTL1 (0.78) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL614739 0.85 L3MBTL1 (0.70) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
Hydrochloric Acid SCHEMBL329950 0.83 L3MBTL1 (0.68) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
Lithium SCHEMBL209869 0.83 L3MBTL1 (0.68) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL209867 0.83 L3MBTL1 (0.68) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL16295141 0.83 MAPT (0.69) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL1431137 0.82 PTK2 (1.00) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL5032454 0.82 L3MBTL1 (0.72) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL26274442 0.82 L3MBTL1 (0.72) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR
SCHEMBL27886037 0.82 TDP1 (0.73) L3MBTL1PTK2RAB9ASMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2909170-A1 SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2015-08-26 EP claimed
US-20150218141-A1 SUBSTITUTED CARBAMATE COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2015-08-06 US claimed
WO-2014060341-A1 SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2014-04-24 WO claimed
CN-114591212-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2025-01-28 CN disclosed
EP-4019022-B1 HUMAN PLASMA KALLIKREIN INHIBITORS BIOCRYST PHARM INC (US) 2024-01-31 EP disclosed
US-11807605-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2023-11-07 US disclosed
EP-4019022-A1 HUMAN PLASMA KALLIKREIN INHIBITORS BioCryst Pharmaceuticals, Inc. (US) 2022-06-29 EP disclosed
EP-3355890-B1 HUMAN PLASMA KALLIKREIN INHIBITORS BIOCRYST PHARM INC (US) 2021-11-10 EP disclosed
US-11066360-B2 Human plasma kallikrein inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2021-07-20 US disclosed
WO-2021127459-A1 GPR139 RECEPTOR MODULATORS BLACKTHORN THERAPEUTICS, INC. (US) 2021-06-24 WO disclosed
US-20200361867-A1 HUMAN PLASMA KALLIKREIN INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2020-11-19 US disclosed
WO-2014060341-A1 SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2014-04-24 WO disclosed
WO-2013163466-A1 INHIBITORS OF HEPATITIS C VIRUS PRESIDIO PHARMACEUTICALS, INC. (US) 2013-10-31 WO disclosed
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed
EP-0033231-B1 INSECTICIDAL COMPOSITIONS CONTAINING 2,6-DIHALOBENZOYLUREA DERIVATIVES ELI LILLY AND COMPANY (US) 1984-06-13 EP disclosed
US-4338321-A FOR INCLUSION IN CATTLE OR POULTRY FEEDS ELI LILLY AND COMPANY (US) 1982-07-06 US disclosed
EP-0033231-A1 Insecticidal compositions containing 2,6-dihalobenzoylurea derivatives ELI LILLY AND COMPANY (US) 1981-08-05 EP disclosed
US-4281003-A 1-(2-6-Dihalobenzoyl)-3-(5-substituted-2-pyridinyl)urea insecticides and insecticidal method ELI LILLY AND COMPANY (US) 1981-07-28 US disclosed
US-3969362-A FUNGICIDE ISHIHARA SANGYO KAISHA LTD. (JA) 1976-07-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11066360-B2 Human plasma kallikrein inhibitors KLKB1, KLK5, KLK1 L3MBTL1 3331/4885PTK2 1287/4885RAB9A 2232/4885
US-20150218141-A1 SUBSTITUTED CARBAMATE COMPOUNDS TRPA1, TRPV1, TRPV3 L3MBTL1 3512/4885PTK2 4388/4885RAB9A 2411/4885
US-11807605-B2 Human plasma kallikrein inhibitors KLKB1, KLK5, KLK1 L3MBTL1 3331/4885PTK2 1287/4885RAB9A 2232/4885
US-20200361867-A1 HUMAN PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 L3MBTL1 3331/4885PTK2 1287/4885RAB9A 2232/4885
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR L3MBTL1 661/4885PTK2 4791/4885RAB9A 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.